Some of our work in adhesion prevention
The following works represent or contain contributions to the field of surgical adhesions by Synechion, Inc., or its principal, Dr. David Wiseman during previous appointments with other companies.
A Meta-analysis of Interceed Barrier Safety/Efficacy Franklin RR, Trout JR, Marks MG, Wiseman D. Interceed Barrier in the prevention of post-operative adhesions following laparotomy: metaanalysis of its efficacy and safety. Fertil. Steril. Prog. Suppl. S227 (1995).
Neutralized Interceed: Adhesion Prevention in the Presence of Blood NEUTRALISED INTERCEED: is even better than INTERCEED and prevents adhesions in the presence of bleeding. It is not yet available. Saferstein L, Wolf S, Kamp L, Linsky CB, Wiseman D. Process for preparing a neutralised oxidized cellulose product and its method of use. US Patent 5,134,229 (1992).
INTERGEL: Iron Cross-linked Hyaluronic Acid INTERGEL (previously Lubricoat), initially developed by Ethicon, Inc. and now under development by Lifecore Biomedical, is a liquid adhesion prevention product. This patent contains much data from preclinical studies conducted by Dr. Wiseman and his group during his appointment with Ethicon Inc., 1991-1993. Johns, DB, Huang, WJ, Kronenthal RL. Ionically crosslinked carboxyl-containing polysaccharides for adhesion prevention. US Patent 5,532,221 (1996).
SprayGel Wiseman DM, Powell M, et al., (2000), “Experimental Evaluation of an Absorbable, Sprayed-on Hydrogel for the Prevention of Pericardial Adhesions,” In preparation.